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Atorvastatin simultaneous use of ranolazine 1000 mg 2 times a day and atorvastatin 80 mg 1 time per day increases the of atorvastatin 1.4 and 1, 3 times, respectively, atorvastatin metabolites vary by no more than 35%. With simultaneous use of ranolazine and atorvasta slime may require dose reduction of atorvastatin and conduct appropriate clinical monitoring. For other statins metabolized with the participation of isoenzyme (lovastatin), you may need a dose adjustment. Tacrolimus, cyclosporine, sirolimus, everolimus Increased plasma concentrations of tacrolimus, substrate isoenzyme, was noted in patients on treatment with…

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