Ranitidine passes into breast milk and it creates a higher plasma concentration. After a single oral administration of 150 mg ranitidine concentration ratio in breast milk. Repeated administration of the drug, these relations have increased. The amount of ranitidine, take the infant with breast milk, which corresponds of the dose received by the mother during breastfeeding. For the above reasons, to take masteron cycle during lactation is contraindicated.
Dosing and Administration
In case of heartburn or other symptoms of dyspepsia should I take.
Tablets should be swallowed whole with a little water. Do not use more than two tablets a day.
Without a doctor’s prescription medication should not be used longer than 14 days.
Side effect From the digestive system: nausea, dry mouth, constipation, vomiting, diarrhea, abdominal pain, jaundice, increased activity of “liver” transaminases; rarely – hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis. From the side of hematopoiesis: leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, neutropenia, immune hemolytic and aplastic anemia, hypo- and aplasia. Cardio-vascular system: decrease in blood pressure, bradycardia , tachycardia, vasculitis, arrhythmia, atrioventricular block. From the nervous system: headache, dizziness, pyrexia, fatigue, drowsiness; insomnia, emotional lability, agitation, anxiety, depression, nervousness, rare – confusion, tinnitus, irritability, hallucinations (mainly in older or severely ill patients), involuntary movements. From the senses: blurred vision, paresis accommodation. From the musculoskeletal system: arthralgia, myalgia. From endocrine system: hyperprolactinemia, gynecomastia, amenorrhea, reduced potency and / or libido. Allergic reactions: urticaria, skin rash, pruritus, angioedema, anaphylactic shock, bronchospasm, multiforme erythema multiforme, including masteron cycle Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis. Other: alopecia, gnperkreatinemiya.
Overdose symptoms: convulsions, bradycardia, ventricular arrhythmias. Treatment: symptomatic. It is shown that the induction of vomiting and / or gastric lavage. With the development of convulsions – diazepam intravenously, with bradycardia – atropine, ventricular aritmiyah- lidocaine. Hemodialysis is effective.
The interaction with other drugs
As a result of increasing the pH of the stomach contents, while the reception can decrease the absorption of itraconazole and ketoconazole.
increasing the concentration of procainamide.
Inhibits hepatic metabolism phenazone, aminophenazone, diazepam, hexobarbital, propranolol, metoprolol, nifedipine, warfarin, lidocaine, phenytoin, theophylline , aminofnllina, indirect anticoagulants.glipizide, buformina, metronidazole, blockers masteron cycle of slow calcium channels.
Drugs that suppress the bone marrow to increase the risk of neutropenia.
In an application with antacids, sucralfate slows down the absorption of ranitidine, so the interval between administration of these medications must be at least 2 hours.
Admission ranitidine with theophylline It may be the cause of the increase in the plasma concentration of theophylline, which may occur as a result of tachycardia, a feeling of depression.
Smoking decreases the effectiveness of ranitidine.