In the first and second trimesters of pregnancy should be prescribed acemethacine only when absolutely necessary. . If acemethacine used in women trying to conceive or in the first and second trimesters of pregnancy, the dose should be kept as low and duration of treatment as short as possible in the third trimester of pregnancy, the use of acemethacine contraindicated.Lactation: Use masteron hair loss of the drug is contraindicated, since small amounts of the active material may come into breast milk.
Dosage and administration
The capsules should be swallowed whole, drinking plenty of fluids during meals. The recommended dose – 1 capsule 1-2 times per day dosing regime at attacks of gout The standard recommended dose for the treatment of acute attacks of gout, to the relief of symptoms of 180 mg acemethacine per day (corresponding to 2 capsules RANTUDIL rETARD). The duration of treatment depends on the clinical picture, but the therapy at doses exceeding 2 capsules of the drug RANTUDIL rETARD a day should last no longer than 7 days.
Very rare: stomatitis, inflammation of the tongue, esophageal lesions, exacerbation of Crohn’s disease or ulcerative colitis, constipation, pancreatitis. From the nervous system: Common: central nervous system disorders including headache, weakness / fatigue, dizziness, drowsiness. Very rarely. muscular asthenia, rash, dysgeusia, memory impairment, sleep disorders, convulsions, cardio-vascular system: Very rare: palpitations, angina pectoris, heart failure, hypertension.liver and biliary tract: Common: increased liver enzymes.
Uncommon: liver disease (chronic hepatitis with or without jaundice it is very rare: fulminant course, and sometimes without any previous symptoms).with side of the masteron hair loss circulatory system: Very rare: anemia caused by loss of occult blood from the gastrointestinal tract, hemolytic anemia, pancytopenia (anemia, including aplastic anemia, leukopenia, agranulocytosis, thrombocytopenia). Initial symptoms may include fever, sore throat, superficial lesions in the mouth, flu-like conditions, severe fatigue, nasal bleeding and subcutaneous bleeding. In these cases, you should immediately stop taking the drug and consult a doctor. It is impossible to independently take analgesics and / or antipyretics. In the case of long-term treatment should be regularly carried out by a blood test. Possible effect on platelet aggregation and increased hemorrhagic diathesis. Immune system: Common: hypersensitivity reactions (rash and itching). Uncommon:. Urticaria Very rare: Severe hypersensitivity reactions: swelling of the face or eyelids, swelling of the tongue, angioneurosis, respiratory distress, which can lead to an asthma attack, decreased blood pressure. Very rare: allergic vasculitis and pneumonitis.
From endocrine system: Very rare: hyperglycaemia and glucosuria. From the side of view: Uncommon: degeneration of retinal pigment, turbidity of the cornea, long-term use of indomethacin , the main metabolite acemethacine. From the hearing: Very rare: tinnitus masteron hair loss and hearing impairment skin and subcutaneous tissue: Uncommon: alopecia Very rare: eczema, enanthema, erythema, photosensitivity, exfoliative dermatitis and bullous rash, which may also be heavy current, for example, in the form of Stevens-Johnson syndrome and toxic epidermal necrolysis (toxic epidermal necrolysis).from the urinary system: Uncommon: development of edema, particularly in patients with hypertension and / or renal dysfunction. Very rare: urination disorders, increasing the level of urea in the blood, acute renal failure, proteinuria, hematuria, interstitial nephritis, nephrotic syndrome, papillary necrosis. in this regard, the patient’s renal function indicators should be monitored regularly.