The drug is rapidly and completely absorbed after ingestion. Absorption begins in the stomach, the maximum plasma concentration of the drug attained in about 40 minutes after administration. The plasma concentration is linearly dependent on the dose of drug administered. Changes in the pharmacokinetics of diclofenac on the background of multiple doses is not happening. Under the recommended interval between meals is no accumulation of the drug. Half-life in plasma of 1-2 hours. Quickly distributed in the body tissues and fluids by. It penetrates into synovial fluid. The maximum concentration of diclofenac observed in the synovial fluid for 2-4 hours later than in plasma. The half-life of diclofenac synovial fluid is 3-6 hours and its concentration in the synovial fluid after 4-6 after dosing remains higher than in the plasma for a further 12 hours. The connection to plasma proteins is high (99%) and a large often associated with albumin. The drug is metabolized in the liver: 50% of the active substance is metabolised during the “first pass” through the liver. Metabolism is the result of a single or multiple hydroxylation and conjugation. The metabolism of the drug is involved enzyme system .
The pharmacological activity of metabolites is lower than that of diclofenac. Deduced drug mainly via the kidneys. Systemic clearance is 260 ml / min.About 60% of the administered dose is excreted through the kidneys in the form of metabolites and less than 1% – unchanged. The rest of the drug is excreted in bile as metabolites. It is noted that the pharmacokinetics of the drug does not vary depending on the age of the patient. For patients with severe renal impairment (creatinine clearance less than 10 mL / min) while the bile excretion of metabolites increases. Thus an increase in their concentration in the blood is not observed.In patients with chronic hepatitis or cirrhosis compensated diclofenac pharmacokinetic masteron only cycle parameters are the same as in patients without liver disease.
Pain syndrome of different origin:
- Pain in muscles and joints (including pain in various parts of the spine, and others.)
- Headache and toothache,
- Pain during menstruation,
relieve symptoms of colds and flu:
- Pain in muscles and joints, headache associated with colds and flu, sore throat.
- Increased body temperature.Contraindications
: Hypersensitivity to diclofenac and other components of the drug; bronchial asthma, urticaria, rhinitis or acute history in response to acetylsalicylic acid or other (such as ibuprofen); period after coronary artery bypass surgery; stomach ulcers, inflammatory bowel disease in the acute stage (nespetsifitsesky ulcerative colitis, Crohn’s disease), ulcer bleeding or perforation; III trimester of pregnancy;expressed severe hepatic, renal (creatinine clearance less than 30 ml / min), or heart failure, progressive renal diseases, confirmed hyperkalemia, hemodyscrasia various hemostatic disorders, bone marrow damage; Children up to age 14 years.
Precautions: coronary heart disease masteron only cycle, cerebrovascular disease, congestive heart failure, dyslipidemiya / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, creatinine clearance less than 60 mL / min. Amnestic data on the development of ulcerative lesions gastrointestinal, old age, long-term use of NSAIDs, frequent alcohol consumption, severe somatic diseases.
Pregnancy and lactation:
In I and II trimesters of pregnancy drug prescribed only if the potential benefit to the mother outweighs the risk to the fetus. The use of diclofenac, as with other are contraindicated in III trimester of pregnancy because of possible uterine atony and / or premature closure of the ductus arteriosus ( the ductus arteriosus ).
Diclofenac, like other enters the mother’s milk in small quantities. Therefore is not recommended during breastfeeding to prevent adverse effects in a child.
Dosing and Administration
Inside adults and children over 14 years:
-. Starting dose is 2 tablets, and then, if necessary, 1-2 tablets every 4-6 hours
. The maximum daily dose is 6 tablets per day (75 mg)
should Pills taken as a whole, without chewing, drinking water.
In order to achieve maximum therapeutic effect, the drug should be taken before meals.
without consultation with the physician, the drug masteron only cycle should be taken no more than 3 days to reduce body temperature and not more than 5 days for the treatment of pain. If the specified time the temperature is reduced and the pain persists, you should consult your doctor immediately!